Role of Kupffer cells in tolerance induction after liver transplantation

Currently, liver transplantation has reached a level of maturity where it is considered an effective treatment for end-stage disease and can significantly prolong the survival time patients. However, acute chronic rejection remain major obstacles to its efficacy. Although long-term use immunosuppressants prevent rejection, associated with serious side effects significant economic burden Therefore, investigation induced immune tolerance holds crucial theoretical significance socio-economic value. In fact, establishment in intricately linked unique innate system liver. Kupffer cells, as component this system, play pivotal role maintaining delicate balance between inflammatory response following transplantation. The important roles different functions such phagocytosis, cell polarization, antigen presentation membrane proteins, after comprehensively summarized paper. Providing basis further study clinical application cells